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human DAG1 shRNA silencing AAV

Name 
AAV-h-DAG1-shRNA
Cat No 
shAAV-206573
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human DAG1.

shAAV-206573
AAV-h-DAG1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human DAG1 (dystroglycan 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
156DAG; A3a; AGRNR; DAG; MDDGA9; MDDGC7; MDDGC9
Description (Vector)
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
Gene ID
1605
Gene Name (Vector)
dystroglycan 1
Gene Symbol
DAG1
HGNC ID
HGNC:2666
ORF Size (aa)
2688
ORF Size (bp)
2688 bp
RefSeq ID
NM_004393
RefSeq Synonyms
NM_004393, NM_001177644, NM_001177643, NM_001177642, NM_001177641, NM_001177640, NM_001177639, NM_001177638, NM_001177637, NM_001177636, NM_001177635, NM_001177634, NM_001165928, BC014616, BC012740,
Species
human
UniGene ID
Hs.707131

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.