human CYP46A1 shRNA silencing AAV

Name
AAV-h-CYP46A1-shRNA

Cat No
shAAV-206508

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CYP46A1.

shAAV-206508

AAV-h-CYP46A1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CYP46A1 (cytochrome P450 family 46 subfamily A member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CP46; CYP46

Description (Vector)

CYP46A1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.

Gene ID

10858

Gene Name (Vector)

cytochrome P450 family 46 subfamily A member 1

Gene Symbol

CYP46A1

HGNC ID

HGNC:2641

ORF Size (aa)

1503

ORF Size (bp)

1503 bp

RefSeq ID

NM_006668

RefSeq Synonyms

NM_006668, BC022539,

Species

human

UniGene ID

Hs.25121

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.