human CYP2C18 shRNA silencing AAV

Name
AAV-h-CYP2C18-shRNA

Cat No
shAAV-206481

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CYP2C18.

shAAV-206481

AAV-h-CYP2C18-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CYP2C18 (cytochrome P450 family 2 subfamily C member 18). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CPCI; CYP2C; CYP2C17; P450-6B/29C; P450IIC17

Description (Vector)

CYP2C18 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

1562

Gene Name (Vector)

cytochrome P450 family 2 subfamily C member 18

Gene Symbol

CYP2C18

HGNC ID

HGNC:2620

ORF Size (aa)

1473

ORF Size (bp)

1473 bp

RefSeq ID

NM_000772

RefSeq Synonyms

NM_001128925, NM_000772, BC096260, BC096258, BC096257, BC069666,

Species

human

UniGene ID

Hs.511872

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.