human CYP11B2 shRNA silencing AAV

Name
AAV-h-CYP11B2-shRNA

Cat No
shAAV-206445

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CYP11B2.

shAAV-206445

AAV-h-CYP11B2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CYP11B2 (cytochrome P450 family 11 subfamily B member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ALDOS; CPN2; CYP11B; CYP11BL; CYPXIB2; P-450C18; P450aldo; P450C18

Description (Vector)

CYP11B2 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency.

Gene ID

1585

Gene Name (Vector)

cytochrome P450 family 11 subfamily B member 2

Gene Symbol

CYP11B2

HGNC ID

HGNC:2592

ORF Size (aa)

1509

ORF Size (bp)

1509 bp

RefSeq ID

NM_000498

RefSeq Synonyms

NM_000498, BC111458,

Species

human

UniGene ID

Hs.632054

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.