human CUL7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CUL7.
shAAV-206304
AAV-h-CUL7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CUL7 (cullin 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3M1; CUL-7; cullin-7; dJ20C7.5; KIAA0076
Description (eCommerce)
Cul7 is a member of the cullin group of proteins and functions as a scaffold to bring together ubiquitin E3 ligases, E2 conjugating enzyme, and substrate proteins to mediate the ubiquitination of substrate proteins. Cul7 has been found to play an essential role in intrauterine growth and development. Cul7 has also been shown to play a role in cell growth through its antagonizing interaction with p53. Alternative names for Cul7 include cullin-7, CUL-7, and KIAA0076.
Description (Vector)
CUL7 is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
9820
Gene Name (eCommerce)
cullin 7
Gene Name (Vector)
cullin 7
Gene Symbol
CUL7
HGNC ID
HGNC:21024
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5097
ORF Size (bp)
5097 bp
Protein Name (eCommerce)
Cullin-7
RefSeq ID
NM_014780
RefSeq Synonyms
NM_014780, NM_001168370, BC033647,
Research Areas
Antigen Processing and Presentation,Cardiovascular,Cell Cycle,Golgi Apparatus,Host-Virus Interactions,Immunology,Ubiquitination
Research Areas (Faceted)
cardiovascular,cell_biology,cell_cycle,infectious_disease,immunology,genetics
Species
human
Target Sentence
Cul7 is a member of the cullin group of proteins and functions as a scaffold to bring together ubiquitin E3 ligases, E2 conjugating enzyme, and substrate proteins to mediate the ubiquitination of substrate proteins. Cul7 has been found to play an essential role in intrauterine growth and development. Cul7 has also been shown to play a role in cell growth through its antagonizing interaction with p53. Alternative names for Cul7 include cullin-7, CUL-7, and KIAA0076.
UniGene ID
Hs.520136
UniProt ID (eCommerce)
Q14999
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.