human CUL4A shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CUL4A.
shAAV-206301
AAV-h-CUL4A-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CUL4A (cullin 4A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CUL-4A; cullin-4A
Description (eCommerce)
Cul4a is a member of the cullin group of proteins and functions as a scaffold to bring together ubiquitin E3 ligases, E2 conjugating enzyme, and substrate proteins to mediate the ubiquitination of substrate proteins. Several Cul4 E3 ligase complexes have been identified as important in cell cycle regulation and the DNA damage checkpoint response.
Description (Vector)
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 (PubMed 19481525)).(supplied by OMIM, Oct 2009)
Gene ID
8451
Gene Name (eCommerce)
cullin 4A
Gene Name (Vector)
cullin 4A
Gene Symbol
CUL4A
HGNC ID
HGNC:2554
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2280
ORF Size (bp)
2280 bp
Protein Name (eCommerce)
Cullin-4A
RefSeq ID
NM_003589
RefSeq Synonyms
NM_003589, NM_001278514, NM_001278513, NM_001008895, BC008308,
Research Areas
Apoptosis,Cell Cycle,DNA Damage/Repair,Host-Virus Interactions,Ubiquitination
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,infectious_disease
Species
human
Target Sentence
Cul4a is a member of the cullin group of proteins and functions as a scaffold to bring together ubiquitin E3 ligases, E2 conjugating enzyme, and substrate proteins to mediate the ubiquitination of substrate proteins. Several Cul4 E3 ligase complexes have been identified as important in cell cycle regulation and the DNA damage checkpoint response.
UniGene ID
Hs.339735
UniProt ID (eCommerce)
Q13619
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.