human CUL2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CUL2.
shAAV-206297
AAV-h-CUL2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CUL2 (cullin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CUL-2; cullin-2; testis secretory sperm-binding protein Li 238E
Description (eCommerce)
Cullin-2 (Cul2) is a core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. Cul2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13617].
Gene ID
8453
Gene Name (eCommerce)
cullin 2
Gene Name (Vector)
cullin 2
Gene Symbol
CUL2
HGNC ID
HGNC:2552
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2238
ORF Size (bp)
2238 bp
Protein Name (eCommerce)
Cullin-2
RefSeq ID
NM_003591
RefSeq Synonyms
NM_003591, NM_001324376, NM_001324375, NM_001198779, NM_001198778, NM_001198777, BC110901, BC009591,
Research Areas
Antigen Processing and Presentation,Apoptosis,Cancer,Cell Cycle,HIF-1 Signaling,Host-Virus Interactions,Hypoxia,Immunology,Kidney Cancer,Signal Transduction,Ubiquitination
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
Cullin-2 (Cul2) is a core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. Cul2 may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13617].
UniGene ID
Hs.82919
UniProt ID (eCommerce)
Q13617
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.