human CTSA shRNA silencing AAV

Name
AAV-h-CTSA-shRNA

Cat No
shAAV-206263

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CTSA.

shAAV-206263

AAV-h-CTSA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CTSA (cathepsin A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GLB2; GSL; NGBE; PPCA; PPGB

Description (Vector)

CTSA encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

5476

Gene Name (Vector)

cathepsin A

Gene Symbol

CTSA

HGNC ID

HGNC:9251

ORF Size (aa)

1440

ORF Size (bp)

1440 bp

RefSeq ID

NM_000308

RefSeq Synonyms

NM_001167594, NM_001127695, NM_000308, BC093009, BC000597,

Species

human

UniGene ID

Hs.609336

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.