human CSE1L shRNA silencing AAV

Name 
AAV-h-CSE1L-shRNA
Cat No 
shAAV-206100
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CSE1L.

shAAV-206100
AAV-h-CSE1L-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CSE1L (chromosome segregation 1 like). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CAS; cellular apoptosis susceptibility protein; chromosome segregation 1-like protein; CSE1; CSE1 chromosome segregation 1-like; epididymis secretory sperm binding protein; exp2; exportin-2; importin-alpha re-exporter; XPO2
Description (eCommerce)
CSE1 function to re-export importin-alpha to the cytoplasm after it has transported nuclear localization signal (NLS) containing proteins to the nucleus. CSE1 is also thought to play a role in cell proliferation and the mitotic spindle checkpoint.
Description (Vector)
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.
Gene ID
1434
Gene Name (eCommerce)
chromosome segregation 1 like
Gene Name (Vector)
chromosome segregation 1 like
Gene Symbol
CSE1L
HGNC ID
HGNC:2431
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2916
ORF Size (bp)
2916 bp
Protein Name (eCommerce)
Exportin-2
RefSeq ID
NM_001316
RefSeq Synonyms
NM_001316, NM_001256135, BC109314, BC109313, BC108309,
Research Areas
Apoptosis,Nuclear Import/Export,p53 Signaling,Signal Transduction,Transport
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
CSE1 function to re-export importin-alpha to the cytoplasm after it has transported nuclear localization signal (NLS) containing proteins to the nucleus. CSE1 is also thought to play a role in cell proliferation and the mitotic spindle checkpoint.
UniGene ID
Hs.90073
UniProt ID (eCommerce)
P55060

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.