human CRKL shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CRKL.
shAAV-206021
AAV-h-CRKL-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CRKL (CRK like proto-oncogene, adaptor protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
CRKL encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
Gene ID
1399
Gene Name (Vector)
CRK like proto-oncogene, adaptor protein
Gene Symbol
CRKL
HGNC ID
HGNC:2363
ORF Size (aa)
912
ORF Size (bp)
912 bp
RefSeq ID
NM_005207
RefSeq Synonyms
NM_005207, BC043500,
Species
human
UniGene ID
Hs.592205
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.