human CREM shRNA silencing AAV

Name 
AAV-h-CREM-shRNA
Cat No 
shAAV-205993
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CREM.

shAAV-205993
AAV-h-CREM-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CREM (cAMP responsive element modulator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CREM-2; hCREM-2; ICER
Description (Vector)
CREM encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
Gene ID
1390
Gene Name (Vector)
cAMP responsive element modulator
Gene Symbol
CREM
HGNC ID
HGNC:2352
ORF Size (aa)
738
ORF Size (bp)
738 bp
RefSeq ID
NM_001881
RefSeq Synonyms
NM_183060, NM_183013, NM_183012, NM_183011, NM_182853, NM_182850, NM_182772, NM_182771, NM_182770, NM_182769, NM_182725, NM_182724, NM_182723, NM_182722, NM_182721, NM_182720, NM_182719, NM_182718, NM_182717, NM_181571, NM_001881, NM_001267570, NM_001267569, NM_001267568, NM_001267567, NM_001267566, NM_001267565, NM_001267564, NM_001267563, NM_001267562, BC090051,
Species
human
UniGene ID
Hs.686182

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.