human CR2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CR2.
shAAV-205954
AAV-h-CR2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CR2 (complement C3d receptor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C3DR; CD antigen CD21; CD21; Complement C3d receptor; complement component (3d/Epstein Barr virus) receptor 2; complement component 3d receptor 2; complement receptor type 2; CR; Cr2; CVID7; EBV receptor; Epstein-Barr virus receptor; SLEB9
Description (eCommerce)
Complement receptor type 2 (CR2) is a receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells, and for HNRPU. CR2 participates in B lymphocytes activation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P20023].
Description (Vector)
CR2 encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
1380
Gene Name (eCommerce)
complement C3d receptor 2
Gene Name (Vector)
complement C3d receptor 2
Gene Symbol
CR2
HGNC ID
HGNC:2336
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3279
ORF Size (bp)
3279 bp
Protein Name (eCommerce)
Complement receptor type 2
RefSeq ID
NM_001006658
RefSeq Synonyms
NM_001877, NM_001006658, BC136394, BC090937,
Research Areas
B-cell Receptor Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Signal Transduction
Research Areas (Faceted)
signal_transduction,immunology,infectious_disease,immunology
Species
human
Target Sentence
Complement receptor type 2 (CR2) is a receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells, and for HNRPU. CR2 participates in B lymphocytes activation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P20023].
UniGene ID
Hs.445757
UniProt ID (eCommerce)
P20023
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.