human CPSF6 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CPSF6.
shAAV-205935
AAV-h-CPSF6-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CPSF6 (cleavage and polyadenylation specific factor 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CFIM; CFIM68; CFIM72; cleavage and polyadenylation specific factor 6, 68kDa; cleavage and polyadenylation specificity factor 68 kDa subunit; cleavage and polyadenylation specificity factor subunit 6; cleavage factor Im complex 68 kDa subunit; CPSF 68 kDa subunit; HPBRII-4; HPBRII-7; pre-mRNA cleavage factor I, 68kD subunit; pre-mRNA cleavage factor Im (68kD); pre-mRNA cleavage factor Im 68 kDa subunit; protein HPBRII-4/7
Description (eCommerce)
Cleavage and polyadenylation specific factor 68 (CPSF68) is the 68 kDa subunit of the cleavage factor Im complex (CFIm). The CFIm is a heterodimer composed of a 25 kDa (CPSF5) subunit and either the 59 kDa (CPSF7) or 68 kDa (CPSF6) subunit and is essential to the first step of pre-mRNA 3’-end processing. CPSF68 bears an N-terminal RNA- recognition motif (RRM) that is necessary for binding CPS5.
Description (Vector)
CPSF6 is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.
Gene ID
11052
Gene Name (eCommerce)
cleavage and polyadenylation specific factor 6
Gene Name (Vector)
cleavage and polyadenylation specific factor 6
Gene Symbol
CPSF6
HGNC ID
HGNC:13871
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1767
ORF Size (bp)
1767 bp
Protein Name (eCommerce)
Cleavage and polyadenylation specificity factor subunit 6
RefSeq ID
NM_007007
RefSeq Synonyms
NM_007007, NM_001300947, BC005000, BC000714,
Research Areas
FGF Signaling,mRNA Binding,mRNA Processing,RNA Binding,RNA Processing,Signal Transduction
Research Areas (Faceted)
cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
Cleavage and polyadenylation specific factor 68 (CPSF68) is the 68 kDa subunit of the cleavage factor Im complex (CFIm). The CFIm is a heterodimer composed of a 25 kDa (CPSF5) subunit and either the 59 kDa (CPSF7) or 68 kDa (CPSF6) subunit and is essential to the first step of pre-mRNA 3’-end processing. CPSF68 bears an N-terminal RNA- recognition motif (RRM) that is necessary for binding CPS5.
UniGene ID
Hs.369606
UniProt ID (eCommerce)
Q16630
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.