human COQ2 shRNA silencing AAV

Name
AAV-h-COQ2-shRNA

Cat No
shAAV-205785

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human COQ2.

shAAV-205785

AAV-h-COQ2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human COQ2 (coenzyme Q2, polyprenyltransferase). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CL640; COQ10D1; MSA1; PHB:PPT

Description (Vector)

COQ2 encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement.

Gene ID

27235

Gene Name (Vector)

coenzyme Q2, polyprenyltransferase

Gene Symbol

COQ2

HGNC ID

HGNC:25223

ORF Size (aa)

1116

ORF Size (bp)

1116 bp

RefSeq ID

NM_015697

RefSeq Synonyms

NM_015697, BC020728, BC008804,

Species

human

UniGene ID

Hs.144304

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.