human COLEC11 shRNA silencing AAV

Name
AAV-h-COLEC11-shRNA

Cat No
shAAV-205727

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human COLEC11.

shAAV-205727

AAV-h-COLEC11-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human COLEC11 (collectin subfamily member 11). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

3MC2; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb; CLK1

Description (Vector)

COLEC11 encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

78989

Gene Name (Vector)

collectin subfamily member 11

Gene Symbol

COLEC11

HGNC ID

HGNC:17213

ORF Size (aa)

807

ORF Size (bp)

807 bp

RefSeq ID

NM_024027

RefSeq Synonyms

NM_199235, NM_024027, NM_001255989, NM_001255988, NM_001255987, NM_001255986, NM_001255985, NM_001255984, NM_001255983, NM_001255982, BC009951, BC000078,

Species

human

UniGene ID

Hs.32603

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.