human COL4A5 shRNA silencing AAV

Name
AAV-h-COL4A5-shRNA

Cat No
shAAV-205708

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human COL4A5.

shAAV-205708

AAV-h-COL4A5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human COL4A5 (collagen type IV alpha 5 chain). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ASLN; ATS; CA54

Description (Vector)

COL4A5 encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene.

Gene ID

1287

Gene Name (Vector)

collagen type IV alpha 5 chain

Gene Symbol

COL4A5

HGNC ID

HGNC:2207

ORF Size (aa)

5076

ORF Size (bp)

5076 bp

RefSeq ID

NM_000495

RefSeq Synonyms

NM_033380, NM_000495, BC151846,

Species

human

UniGene ID

Hs.369089

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.