human COL18A1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human COL18A1.
shAAV-205686
AAV-h-COL18A1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human COL18A1 (collagen type XVIII alpha 1 chain). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
KNO; KNO1; KS
Description (Vector)
COL18A1 encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
80781
Gene Name (Vector)
collagen type XVIII alpha 1 chain
Gene Symbol
COL18A1
HGNC ID
HGNC:2195
ORF Size (aa)
4011
ORF Size (bp)
4011 bp
RefSeq ID
NM_030582
RefSeq Synonyms
NM_130445, NM_130444, NM_030582, BC063833,
Species
human
UniGene ID
Hs.517356
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.