human CNR1 shRNA silencing AAV

Name
AAV-h-CNR1-shRNA

Cat No
shAAV-205627

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CNR1.

shAAV-205627

AAV-h-CNR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CNR1 (cannabinoid receptor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR

Description (Vector)

CNR1 encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.

Gene ID

1268

Gene Name (Vector)

cannabinoid receptor 1

Gene Symbol

CNR1

HGNC ID

HGNC:2159

ORF Size (aa)

1419

ORF Size (bp)

1419 bp

RefSeq ID

NM_033181

RefSeq Synonyms

NM_033181, NM_016083, NM_001160259, NM_001160258, NM_001160226, BC100971, BC100970, BC100969, BC100968, BC074812, BC074811,

Species

human

UniGene ID

Hs.709067

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.