human CNOT2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CNOT2.
shAAV-205606
AAV-h-CNOT2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CNOT2 (CCR4-NOT transcription complex subunit 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CDC36; HSPC131; negative regulator of transcription 2; NOT2; NOT2H
Description (eCommerce)
CCR4-NOT transcription complex subunit 2 (CNOT2) is a subunit of the CCR4-NOT core complex that functions as a general transcriptional regulator.
Description (Vector)
CNOT2 encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene.
Gene ID
4848
Gene Name (eCommerce)
CCR4-NOT transcription complex subunit 2
Gene Name (Vector)
CCR4-NOT transcription complex subunit 2
Gene Symbol
CNOT2
HGNC ID
HGNC:7878
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1623
ORF Size (bp)
1623 bp
Protein Name (eCommerce)
CCR4-NOT transcription complex subunit 2
RefSeq ID
NM_014515
RefSeq Synonyms
NM_014515, NM_001199303, NM_001199302, BC011826, BC002597,
Research Areas
Gene Expression,RNA Processing,Transcription Factor/Regulator,Translational Control
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
CCR4-NOT transcription complex subunit 2 (CNOT2) is a subunit of the CCR4-NOT core complex that functions as a general transcriptional regulator.
UniGene ID
Hs.133350
UniProt ID (eCommerce)
Q9NZN8
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.