human CMA1 shRNA silencing AAV

Name
AAV-h-CMA1-shRNA

Cat No
shAAV-205538

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CMA1.

shAAV-205538

AAV-h-CMA1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CMA1 (chymase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

chymase; CYH; MCT1

Description (Vector)

CMA1 product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. CMA1 maps to 14q11.2 in a cluster of genes encoding other proteases.

Gene ID

1215

Gene Name (Vector)

chymase 1

Gene Symbol

CMA1

HGNC ID

HGNC:2097

ORF Size (aa)

411

ORF Size (bp)

411 bp

RefSeq ID

NM_001836

RefSeq Synonyms

NM_001836, NM_001308083, BC103975, BC103974, BC069490, BC069370, BC069110,

Species

human

UniGene ID

Hs.135626

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.