human CLTC shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CLTC.
shAAV-205527
AAV-h-CLTC-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CLTC (clathrin heavy chain). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CHC; CHC17; clathrin heavy chain 1; clathrin heavy chain on chromosome 17; clathrin, heavy polypeptide (Hc); clathrin, heavy polypeptide-like 2; CLH-17; CLTCL2; Hc; MRD56
Description (eCommerce)
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains [taken from NCBI Entrez Gene (Gene ID: 1213)].www.uniprot.org/uniprot/Q00610].
Description (Vector)
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.
Gene ID
1213
Gene Name (eCommerce)
clathrin heavy chain
Gene Name (Vector)
clathrin heavy chain
Gene Symbol
CLTC
HGNC ID
HGNC:2092
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4920
ORF Size (bp)
4920 bp
Protein Name (eCommerce)
Clathrin heavy chain 1
RefSeq ID
NM_004859
RefSeq Synonyms
NM_004859, NM_001288653, BC054489, BC051800,
Research Areas
Antigen Processing and Presentation,Axon Guidance,CD95/FAS Signaling,Cell Cycle,EGFR Signaling,Golgi Apparatus,Host-Virus Interactions,Huntington's Disease,Immunology,Lysosome,Mitochondrion,Neurobiology,Neurodegeneration,NGF Signaling,Signal Transduction,T-cell Receptor Signaling,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains [taken from NCBI Entrez Gene (Gene ID: 1213)].www.uniprot.org/uniprot/Q00610].
UniGene ID
Hs.663896
UniProt ID (eCommerce)
Q00610
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.