human CLN5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CLN5.
shAAV-205483
AAV-h-CLN5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CLN5 (ceroid-lipofuscinosis, neuronal 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
NCL
Description (Vector)
CLN5 is one of eight which have been associated with neuronal ceroid lipofuscinoses (NCL). Also referred to as Batten disease, NCL comprises a class of autosomal recessive, neurodegenerative disorders affecting children. The genes responsible likely encode proteins involved in the degradation of post-translationally modified proteins in lysosomes. The primary defect in NCL disorders is thought to be associated with lysosomal storage function.
Gene ID
1203
Gene Name (Vector)
ceroid-lipofuscinosis, neuronal 5
Gene Symbol
CLN5
HGNC ID
HGNC:2076
ORF Size (aa)
1224
ORF Size (bp)
1224 bp
RefSeq ID
NM_006493
RefSeq Synonyms
NM_006493, BC172583, BC153154, BC146274,
Species
human
UniGene ID
Hs.30213
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.