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human CLCNKB shRNA silencing AAV

Name 
AAV-h-CLCNKB-shRNA
Cat No 
shAAV-205361
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CLCNKB.

shAAV-205361
AAV-h-CLCNKB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CLCNKB (chloride voltage-gated channel Kb). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ClC-K2; ClC-Kb; CLCKB
Description (Vector)
CLCNKB is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
1188
Gene Name (Vector)
chloride voltage-gated channel Kb
Gene Symbol
CLCNKB
HGNC ID
HGNC:2027
ORF Size (aa)
1389
ORF Size (bp)
1389 bp
RefSeq ID
NM_000085
RefSeq Synonyms
NM_001165945, NM_000085, BC020873,
Species
human
UniGene ID
Hs.352243

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.