human CLCN7 shRNA silencing AAV

Name 
AAV-h-CLCN7-shRNA
Cat No 
shAAV-205358
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CLCN7.

shAAV-205358
AAV-h-CLCN7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CLCN7 (chloride voltage-gated channel 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
chloride channel 7 alpha subunit; chloride channel protein 7; chloride channel, voltage-sensitive 7; CLC7; CLC-7; H(+)/Cl(-) exchange transporter 7; OPTA2; OPTB4; PPP1R63; protein phosphatase 1, regulatory subunit 63
Description (eCommerce)
Chloride channel protein 7 (CLCN7) is a voltage-gated channel mediating the exchange of chloride ions against protons. CLCN7 functions as antiporter and contributes to the acidification of the lysosome lumen [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P51798].
Description (Vector)
The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood.
Gene ID
1186
Gene Name (eCommerce)
chloride voltage-gated channel 7
Gene Name (Vector)
chloride voltage-gated channel 7
Gene Symbol
CLCN7
HGNC ID
HGNC:2025
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2418
ORF Size (bp)
2418 bp
Protein Name (eCommerce)
H(+)/Cl(-) exchange transporter 7
RefSeq ID
NM_001287
RefSeq Synonyms
NM_001287, NM_001114331, BC012737,
Research Areas
Kinase/Phosphatase,Lysosome,Neurobiology
Research Areas (Faceted)
cell_biology,neurobiology,signal_transduction
Species
human
Target Sentence
Chloride channel protein 7 (CLCN7) is a voltage-gated channel mediating the exchange of chloride ions against protons. CLCN7 functions as antiporter and contributes to the acidification of the lysosome lumen [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P51798].
UniGene ID
Hs.459649
UniProt ID (eCommerce)
P51798

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.