human CLCN1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CLCN1.
shAAV-205346
AAV-h-CLCN1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CLCN1 (chloride voltage-gated channel 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CLC1
Description (Vector)
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants.
Gene ID
1180
Gene Name (Vector)
chloride voltage-gated channel 1
Gene Symbol
CLCN1
HGNC ID
HGNC:2019
ORF Size (aa)
2967
ORF Size (bp)
2967 bp
RefSeq ID
NM_000083
RefSeq Synonyms
NM_000083, BC113495, BC112156, BC111586,
Species
human
UniGene ID
Hs.121483
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.