human CKMT2 shRNA silencing AAV

Name
AAV-h-CKMT2-shRNA

Cat No
shAAV-205325

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CKMT2.

shAAV-205325

AAV-h-CKMT2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CKMT2 (creatine kinase, mitochondrial 2). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

SMTCK

Description (Vector)

Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gene.

Gene ID

1160

Gene Name (Vector)

creatine kinase, mitochondrial 2

Gene Symbol

CKMT2

HGNC ID

HGNC:1996

ORF Size (aa)

1260

ORF Size (bp)

1260 bp

RefSeq ID

NM_001825

RefSeq Synonyms

NM_001825, NM_001099736, NM_001099735, BC029140,

Species

human

UniGene ID

Hs.80691

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.