human CISH shRNA silencing AAV

Name
AAV-h-CISH-shRNA

Cat No
shAAV-205295

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CISH.

shAAV-205295

AAV-h-CISH-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CISH (cytokine inducible SH2 containing protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BACTS2; CIS; CIS-1; G18; SOCS

Description (Vector)

CISH contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

1154

Gene Name (Vector)

cytokine inducible SH2 containing protein

Gene Symbol

CISH

HGNC ID

HGNC:1984

ORF Size (aa)

777

ORF Size (bp)

777 bp

RefSeq ID

NM_013324

RefSeq Synonyms

NM_145071, NM_013324, BC064354, BC031590,

Species

human

UniGene ID

Hs.655334

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.