human CILP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CILP.
shAAV-205284
AAV-h-CILP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CILP (cartilage intermediate layer protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CILP-1; HsT18872
Description (Vector)
Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease.
Gene ID
8483
Gene Name (Vector)
cartilage intermediate layer protein
Gene Symbol
CILP
HGNC ID
HGNC:1980
ORF Size (aa)
3555
ORF Size (bp)
3555 bp
RefSeq ID
NM_003613
RefSeq Synonyms
NM_003613, BC035776,
Species
human
UniGene ID
Hs.442180
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.