human DCP1A Over-expression AAV

Name 
AAV-h-DCP1A
Cat No 
AAV-206663
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human DCP1A.

AAV-206663
AAV-h-DCP1A

Ready-to-use AAV expressing Human DCP1A (decapping mRNA 1A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DCP1 decapping enzyme homolog A; DCP1 decapping enzyme-like protein A; decapping enzyme hDcp1a; HSA275986; mRNA-decapping enzyme 1A; Nbla00360; putative protein product of Nbla00360; Smad4-interacting transcriptional co-activator; SMAD4IP1; SMIF; transcription factor SMIF
Description (eCommerce)
mRNA-decapping enzyme 1A (DCP1A) is necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. DCP1A removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. DCP1A also contributes to the transactivation of target genes after stimulation by TGFB1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9NPI6].
Description (Vector)
Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway.
Gene ID
55802
Gene Name (eCommerce)
decapping mRNA 1A
Gene Name (Vector)
decapping mRNA 1A
Gene Symbol
DCP1A
HGNC ID
HGNC:18714
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1749
ORF Size (bp)
1749 bp
Protein Name (eCommerce)
mRNA-decapping enzyme 1A
RefSeq ID
NM_018403
RefSeq Synonyms
NM_018403, NM_001290207, NM_001290206, NM_001290205, NM_001290204, BC007439,
Research Areas
Gene Expression,mRNA Binding,RNA Processing,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
mRNA-decapping enzyme 1A (DCP1A) is necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. DCP1A removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. DCP1A also contributes to the transactivation of target genes after stimulation by TGFB1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9NPI6].
UniGene ID
Hs.476353
UniProt ID (eCommerce)
Q9NPI6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.