human CHRNG shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CHRNG.
shAAV-205233
AAV-h-CHRNG-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CHRNG (cholinergic receptor nicotinic gamma subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ACHRG
Description (Vector)
The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.
Gene ID
1146
Gene Name (Vector)
cholinergic receptor nicotinic gamma subunit
Gene Symbol
CHRNG
HGNC ID
HGNC:1967
ORF Size (aa)
1398
ORF Size (bp)
1398 bp
RefSeq ID
NM_005199
RefSeq Synonyms
NM_005199, BC111802,
Species
human
UniGene ID
Hs.248101
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.