human CHRND shRNA silencing AAV

Name
AAV-h-CHRND-shRNA

Cat No
shAAV-205229

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CHRND.

shAAV-205229

AAV-h-CHRND-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CHRND (cholinergic receptor nicotinic delta subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACHRD; CMS2A; CMS3A; CMS3B; CMS3C; FCCMS; SCCMS

Description (Vector)

The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in this gene are a cause of multiple pterygium syndrome lethal type (MUPSL), congenital myasthenic syndrome slow-channel type (SCCMS), and congenital myasthenic syndrome fast-channel type (FCCMS). Several transcript variants, some protein-coding and some not, have been found for this gene.

Gene ID

1144

Gene Name (Vector)

cholinergic receptor nicotinic delta subunit

Gene Symbol

CHRND

HGNC ID

HGNC:1965

ORF Size (aa)

1554

ORF Size (bp)

1554 bp

RefSeq ID

NM_000751

RefSeq Synonyms

NM_001311196, NM_001311195, NM_001256657, NM_000751, BC093925, BC093923,

Species

human

UniGene ID

Hs.156289

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.