human CHRNA4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CHRNA4.
shAAV-205213
AAV-h-CHRNA4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CHRNA4 (cholinergic receptor nicotinic alpha 4 subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BFNC; EBN; EBN1; NACHR; NACHRA4; NACRA4
Description (Vector)
CHRNA4 encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants.
Gene ID
1137
Gene Name (Vector)
cholinergic receptor nicotinic alpha 4 subunit
Gene Symbol
CHRNA4
HGNC ID
HGNC:1958
ORF Size (aa)
1671
ORF Size (bp)
1671 bp
RefSeq ID
NM_000744
RefSeq Synonyms
NM_001256573, NM_000744, BC096293, BC096292, BC096291, BC096290,
Species
human
UniGene ID
Hs.10734
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.