human CHMP4B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CHMP4B.
shAAV-205166
AAV-h-CHMP4B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CHMP4B (charged multivesicular body protein 4B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C20orf178; CHMP4A; CTPP3; CTRCT31; dJ553F4.4; Shax1; SNF7; SNF7-2; Vps32-2; VPS32B
Description (Vector)
CHMP4B encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
Gene ID
128866
Gene Name (Vector)
charged multivesicular body protein 4B
Gene Symbol
CHMP4B
HGNC ID
HGNC:16171
ORF Size (aa)
675
ORF Size (bp)
675 bp
RefSeq ID
NM_176812
RefSeq Synonyms
NM_176812, BC033859,
Species
human
UniGene ID
Hs.472471
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.