human CFL2 shRNA silencing AAV

Name
AAV-h-CFL2-shRNA

Cat No
shAAV-205053

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CFL2.

shAAV-205053

AAV-h-CFL2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CFL2 (cofilin 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

NEM7

Description (Vector)

CFL2 encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.

Gene ID

1073

Gene Name (Vector)

cofilin 2

Gene Symbol

CFL2

HGNC ID

HGNC:1875

ORF Size (aa)

501

ORF Size (bp)

501 bp

RefSeq ID

NM_021914

RefSeq Synonyms

NM_138638, NM_021914, NM_001243645, BC022876, BC022364, BC011444,

Species

human

UniGene ID

Hs.180141

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.