human CES1 shRNA silencing AAV

Name
AAV-h-CES1-shRNA

Cat No
shAAV-205020

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CES1.

shAAV-205020

AAV-h-CES1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CES1 (carboxylesterase 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ACAT; CE-1; CEH; CES2; hCE-1; HMSE; HMSE1; PCE-1; REH; SES1; TGH

Description (Vector)

CES1 encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.

Gene ID

1066

Gene Name (Vector)

carboxylesterase 1

Gene Symbol

CES1

HGNC ID

HGNC:1863

ORF Size (aa)

1701

ORF Size (bp)

1701 bp

RefSeq ID

NM_001266

RefSeq Synonyms

NM_001266, NM_001025195, NM_001025194, BC110338, BC012418,

Species

human

UniGene ID

Hs.558865

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.