human CEBPB shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CEBPB.
shAAV-204936
AAV-h-CEBPB-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CEBPB (CCAAT/enhancer binding protein beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C/EBP beta; C/EBP-beta; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta; IL6DBP; interleukin 6-dependent DNA-binding protein; LAP; LIP; Liver activator protein; Liver-enriched inhibitory protein; NF-IL6; nuclear factor NF-IL6; nuclear factor of interleukin 6; TCF5; TCF-5; transcription factor 5; transcription factor C/EBP beta
Description (eCommerce)
CCAAT/enhancer binding protein beta (C/EBP beta) is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. C/EBP beta is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes [taken from NCBI Entrez Gene (GeneID: 1051)].
Description (Vector)
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.
Gene ID
1051
Gene Name (eCommerce)
CCAAT enhancer binding protein beta
Gene Name (Vector)
CCAAT/enhancer binding protein beta
Gene Symbol
CEBPB
HGNC ID
HGNC:1834
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1038
Protein Name (eCommerce)
CCAAT/enhancer-binding protein beta
RefSeq ID
NM_005194
RefSeq Synonyms
NM_005194, NM_001285879, NM_001285878, BC021931, BC007538,
Research Areas
Aging,Apoptosis,Autophagy,Cancer,EGFR Signaling,IFN Signaling,Immunology,Interleukin Signaling,Neurobiology,Neurodevelopment,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Transcription Factor/Regulator,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
CCAAT/enhancer binding protein beta (C/EBP beta) is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. C/EBP beta is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes [taken from NCBI Entrez Gene (GeneID: 1051)].
UniGene ID
Hs.701858
UniProt ID (eCommerce)
P17676
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.