human CEACAM1 shRNA silencing AAV

Name
AAV-h-CEACAM1-shRNA

Cat No
shAAV-204922

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CEACAM1.

shAAV-204922

AAV-h-CEACAM1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CEACAM1 (carcinoembryonic antigen related cell adhesion molecule 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

antigen CD66; BGP; BGP1; BGP-1; BGPI; Biliary glycoprotein 1; carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); CD antigen CD66a; CD66a antigen

Description (eCommerce)

Carcinoembryonic antigen related cell adhesion molecules 1 and 5 (CEACAM1 and CEACAM5) are members of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. CEACAM1 was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. CEACAM5 is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, CEACAM5 may regulate differentiation, apoptosis, and cell polarity.

Description (Vector)

CEACAM1 encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.

Gene ID

634

Gene Name (eCommerce)

carcinoembryonic antigen related cell adhesion molecule 1

Gene Name (Vector)

carcinoembryonic antigen related cell adhesion molecule 1

Gene Symbol

CEACAM1

HGNC ID

HGNC:1814

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1407

ORF Size (bp)

1407 bp

Protein Name (eCommerce)

Carcinoembryonic antigen-related cell adhesion molecule 1

RefSeq ID

NM_001712

RefSeq Synonyms

NM_001712, NM_001205344, NM_001184816, NM_001184815, NM_001184813, NM_001024912, BC014473,

Research Areas

Angiogenesis,Immunology,Signal Transduction

Research Areas (Faceted)

cancer,developmental_biology,immunology,signal_transduction

Species

human

Target Sentence

UniGene ID

Hs.512682

UniProt ID (eCommerce)

P13688

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.