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human CDK5RAP3 shRNA silencing AAV

Name 
AAV-h-CDK5RAP3-shRNA
Cat No 
shAAV-204857
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CDK5RAP3.

shAAV-204857
AAV-h-CDK5RAP3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CDK5RAP3 (CDK5 regulatory subunit associated protein 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C53; CDK5 activator-binding protein C53; CDK5 regulatory subunit associated protein IC53-2; CDK5 regulatory subunit-associated protein 3; HSF-27; IC53; ischemic heart CDK5 activator-binding protein C53; LXXLL/leucine-zipper-containing ARFbinding protein; LXXLL/leucine-zipper-containing ARF-binding protein; LZAP; MST016; OK/SW-cl.114; PP1553; Protein HSF-27
Description (eCommerce)
CDK5RAP3 (CDK5 regulatory subunit-associated protein 3) was identified as a protein that associates with the activating subunit of Cdk5, p25NCK5A. Cdk5 is a brain specific cyclin-dependent kinase important to mammalian brain development; however CDK5RAP3 appears to be widely expressed in human tissues. CDK5RAP3 appears to exhibit functions that extend beyond its association with Cdk5. CDK5RAP3 is involved in modulating the G2/M DNA damage checkpoint and can associate with and regulate the Cdk1-cyclin B1 complex. CDK5RAP3 has also been demonstrated to interact with and regulate the tumor suppressor ARF (alternative reading frame) to further play a role in cell cycle progression.
Description (Vector)
Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.
Gene ID
80279
Gene Name (eCommerce)
CDK5 regulatory subunit associated protein 3
Gene Name (Vector)
CDK5 regulatory subunit associated protein 3
Gene Symbol
CDK5RAP3
HGNC ID
HGNC:18673
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1521
ORF Size (bp)
1521 bp
Protein Name (eCommerce)
CDK5 regulatory subunit-associated protein 3
RefSeq ID
NM_176096
RefSeq Synonyms
NM_176096, NM_001278217, NM_001278216, NM_001278198, NM_001278197, BC072435, BC009957,
Research Areas
Brain Development,DNA Damage/Repair,Immunology,Neurobiology,Neurodevelopment
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,immunology,neurobiology,transcription_translation
Species
human
Target Sentence
CDK5RAP3 (CDK5 regulatory subunit-associated protein 3) was identified as a protein that associates with the activating subunit of Cdk5, p25NCK5A. Cdk5 is a brain specific cyclin-dependent kinase important to mammalian brain development; however CDK5RAP3 appears to be widely expressed in human tissues. CDK5RAP3 appears to exhibit functions that extend beyond its association with Cdk5. CDK5RAP3 is involved in modulating the G2/M DNA damage checkpoint and can associate with and regulate the Cdk1-cyclin B1 complex. CDK5RAP3 has also been demonstrated to interact with and regulate the tumor suppressor ARF (alternative reading frame) to further play a role in cell cycle progression.
UniGene ID
Hs.20157
UniProt ID (eCommerce)
Q96JB5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.