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human CDK2AP1 shRNA silencing AAV

Name 
AAV-h-CDK2AP1-shRNA
Cat No 
shAAV-204840
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CDK2AP1.

shAAV-204840
AAV-h-CDK2AP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CDK2AP1 (cyclin dependent kinase 2 associated protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
doc-1; DOC1; DORC1; p12DOC-1; ST19
Description (Vector)
CDK2AP1 is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene ID
8099
Gene Name (Vector)
cyclin dependent kinase 2 associated protein 1
Gene Symbol
CDK2AP1
HGNC ID
HGNC:14002
ORF Size (aa)
348
RefSeq ID
NM_004642
RefSeq Synonyms
NM_004642, NM_001270434, NM_001270433, BC034717,
Species
human
UniGene ID
Hs.433201

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.