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human CDCA2 shRNA silencing AAV

Name 
AAV-h-CDCA2-shRNA
Cat No 
shAAV-204784
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CDCA2.

shAAV-204784
AAV-h-CDCA2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CDCA2 (cell division cycle associated 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
cell division cycle-associated protein 2; PPP1R81; protein phosphatase 1, regulatory subunit 81; recruits PP1 onto mitotic chromatin at anaphase protein; Repo-Man
Description (eCommerce)
CDCA2 is a regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q69YH5].
Gene ID
157313
Gene Name (eCommerce)
cell division cycle associated 2
Gene Name (Vector)
cell division cycle associated 2
Gene Symbol
CDCA2
HGNC ID
HGNC:14623
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2592
ORF Size (bp)
2592 bp
Protein Name (eCommerce)
Cell division cycle-associated protein 2
RefSeq ID
NM_152562
RefSeq Synonyms
NM_152562, NM_001317907, NM_001317906, BC036214,
Research Areas
Cell Cycle,Cell Division,Kinase/Phosphatase
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,signal_transduction
Species
human
Target Sentence
CDCA2 is a regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q69YH5].
UniGene ID
Hs.33366
UniProt ID (eCommerce)
Q69YH5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.