human CDC2L5 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CDK13.
shAAV-204747
AAV-h-CDC2L5-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CDK13 (cyclin dependent kinase 13). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CDC2L; CDC2L5; CDC2-related protein kinase 5; cell division cycle 2-like protein kinase 5; cell division protein kinase 13; CHDFIDD; CHED; cholinesterase-related cell division controller; cyclin-dependent kinase 13; hCDK13
Description (eCommerce)
CDC2-like kinase 5 (CDC2L5) is a member of the cyclin-dependent serine/threonine protein kinase family that plays a central role in cell cycle control. The CDC2L5 cDNA was first identified as CHED (cholinesterase-related cell-division controller) and cloned serendipitously in a screen using a cholinesterase-specific oligonucleotide probe in search of a link between cholinergic signaling and hematopoietic cell division control. Recently, the understanding of the physiological function of CDC2L5 has become clearer. Due to its localization to speckles in the nucleoplasm and its interaction with the splicing protein, ASF/SF2-associated protein p32, it was suggested to play a role in mRNA processing. Further studies showed that overexpression of CDC2L5 altered mRNA splicing patterns, and that CDC2L5 associated with L-type cyclins known to be involved in alternative splicing. These results have led to the conclusion that CDC2L5 is part of a subfamily of cyclin dependent kinases that play a role in the regulation of alternative splicing.
Description (Vector)
CDK13 is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.
Gene ID
8621
Gene Name (eCommerce)
cyclin dependent kinase 13
Gene Name (Vector)
cyclin dependent kinase 13
Gene Symbol
CDK13
HGNC ID
HGNC:1733
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4539
ORF Size (bp)
4539 bp
Protein Name (eCommerce)
Cyclin-dependent kinase 13
RefSeq ID
NM_003718
RefSeq Synonyms
NM_031267, NM_003718, BC168380, BC001274,
Research Areas
Cell Cycle,Host-Virus Interactions,Kinase/Phosphatase,mRNA Processing,mRNA Splicing,RNA Processing,Spliceosome
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
CDC2-like kinase 5 (CDC2L5) is a member of the cyclin-dependent serine/threonine protein kinase family that plays a central role in cell cycle control. The CDC2L5 cDNA was first identified as CHED (cholinesterase-related cell-division controller) and cloned serendipitously in a screen using a cholinesterase-specific oligonucleotide probe in search of a link between cholinergic signaling and hematopoietic cell division control. Recently, the understanding of the physiological function of CDC2L5 has become clearer. Due to its localization to speckles in the nucleoplasm and its interaction with the splicing protein, ASF/SF2-associated protein p32, it was suggested to play a role in mRNA processing. Further studies showed that overexpression of CDC2L5 altered mRNA splicing patterns, and that CDC2L5 associated with L-type cyclins known to be involved in alternative splicing. These results have led to the conclusion that CDC2L5 is part of a subfamily of cyclin dependent kinases that play a role in the regulation of alternative splicing.
UniGene ID
Hs.233552
UniProt ID (eCommerce)
Q14004
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.