human CD80 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CD80.
shAAV-204686
AAV-h-CD80-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CD80 (CD80 molecule). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD antigen CD80; CD28LG; CD28LG1; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; LAB7; T-lymphocyte activation antigen CD80
Description (eCommerce)
CD80 is a membrane receptor involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P33681].
Description (Vector)
CD80 is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy.
Gene ID
941
Gene Name (eCommerce)
CD80 molecule
Gene Name (Vector)
CD80 molecule
Gene Symbol
CD80
HGNC ID
HGNC:1700
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
867
ORF Size (bp)
867 bp
Protein Name (eCommerce)
T-lymphocyte activation antigen CD80
RefSeq ID
NM_005191
RefSeq Synonyms
NM_005191, BC042665,
Research Areas
B-cell Receptor Signaling,Cancer,Cardiology,Cardiovascular,EGFR Signaling,EGFR Signaling in Cancer,Fc Receptor Signaling,FGF Signaling,GPCR Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Interleukin Signaling,Neurobiology,NF-kB Signaling,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,Toll-like Receptor Signaling
Research Areas (Faceted)
cancer,cardiovascular,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology
Species
human
Target Sentence
CD80 is a membrane receptor involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P33681].
UniGene ID
Hs.838
UniProt ID (eCommerce)
P33681
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.