human CD46 shRNA silencing AAV

Name
AAV-h-CD46-shRNA

Cat No
shAAV-204657

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CD46.

shAAV-204657

AAV-h-CD46-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CD46 (CD46 molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AHUS2; MCP; MIC10; TLX; TRA2.10

Description (Vector)

CD46 is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene ID

4179

Gene Name (Vector)

CD46 molecule

Gene Symbol

CD46

HGNC ID

HGNC:6953

ORF Size (aa)

1155

ORF Size (bp)

1155 bp

RefSeq ID

NM_002389

RefSeq Synonyms

NM_172361, NM_172359, NM_172353, NM_172352, NM_172351, NM_172350, NM_153826, NM_002389, BC030594,

Species

human

UniGene ID

Hs.510402

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.