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human CD3E shRNA silencing AAV

Name 
AAV-h-CD3E-shRNA
Cat No 
shAAV-204647
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human CD3E.

shAAV-204647
AAV-h-CD3E-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CD3E (CD3e molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3-epsilon; IMD18; T3E; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; TCRE
Description (eCommerce)
CD3E is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The epsilon polypeptide plays an essential role in T-cell development [taken from NCBI Entrez Gene (Gene ID: 916)].
Description (Vector)
CD3E is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
Gene ID
916
Gene Name (eCommerce)
CD3 epsilon subunit of T-cell receptor complex
Gene Name (Vector)
CD3e molecule
Gene Symbol
CD3E
HGNC ID
HGNC:1674
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
624
ORF Size (bp)
624 bp
Protein Name (eCommerce)
T-cell surface glycoprotein CD3 epsilon chain
RefSeq ID
NM_000733
RefSeq Synonyms
NM_000733, BC049847,
Research Areas
Apoptosis,Host-Virus Interactions,Immune Cells and Tumor Markers,Immunology,Immuno-Oncology,Interleukin Signaling,Neurobiology,NF-kB Signaling,Prolactin Signaling,Signal Transduction,immunology,cell_biology,T-cell Receptor Signaling
Research Areas (Faceted)
cell_biology,immuno_oncology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
CD3E is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The epsilon polypeptide plays an essential role in T-cell development [taken from NCBI Entrez Gene (Gene ID: 916)].
UniGene ID
Hs.3003
UniProt ID (eCommerce)
P07766

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.