human CCR1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CCR1.
shAAV-204529
AAV-h-CCR1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CCR1 (C-C motif chemokine receptor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD191; CKR-1; CKR1; CMKBR1; HM145; MIP1aR; SCYAR1
Description (Vector)
CCR1 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. CCR1 and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.
Gene ID
1230
Gene Name (Vector)
C-C motif chemokine receptor 1
Gene Symbol
CCR1
HGNC ID
HGNC:1602
ORF Size (aa)
1068
ORF Size (bp)
1068 bp
RefSeq ID
NM_001295
RefSeq Synonyms
NM_001295, BC064991, BC051306,
Species
human
UniGene ID
Hs.301921
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.