human CCND2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human CCND2.
shAAV-204491
AAV-h-CCND2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human CCND2 (cyclin D2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
KIAK0002; MPPH3
Description (Vector)
CCND2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
Gene ID
894
Gene Name (Vector)
cyclin D2
Gene Symbol
CCND2
HGNC ID
HGNC:1583
ORF Size (aa)
870
ORF Size (bp)
870 bp
RefSeq ID
NM_001759
RefSeq Synonyms
NM_001759, BC089384, BC010958,
Species
human
UniGene ID
Hs.376071
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.