human CCND1 shRNA silencing AAV

Name
AAV-h-CCND1-shRNA

Cat No
shAAV-204486

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human CCND1.

shAAV-204486

AAV-h-CCND1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CCND1 (cyclin D1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BCL1; D11S287E; PRAD1; U21B31

Description (Vector)

CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Gene ID

595

Gene Name (Vector)

cyclin D1

Gene Symbol

CCND1

HGNC ID

HGNC:1582

ORF Size (aa)

888

ORF Size (bp)

888 bp

RefSeq ID

NM_053056

RefSeq Synonyms

NM_053056, BC025302, BC023620, BC014078, BC001501, BC000076,

Species

human

UniGene ID

Hs.523852

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.