human CCL5 shRNA silencing AAV

Name
AAV-h-CCL5-shRNA

Cat No
shAAV-204464

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CCL5.

shAAV-204464

AAV-h-CCL5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CCL5 (C-C motif chemokine ligand 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

D17S136E; eoCP; RANTES; SCYA5; SIS-delta; SISd; TCP228

Description (Vector)

CCL5 is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.

Gene ID

6352

Gene Name (Vector)

C-C motif chemokine ligand 5

Gene Symbol

CCL5

HGNC ID

HGNC:10632

ORF Size (aa)

276

RefSeq ID

NM_002985

RefSeq Synonyms

NM_002985, NM_001278736, BC008600,

Species

human

UniGene ID

Hs.514821

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.