human CCL22 shRNA silencing AAV

Name
AAV-h-CCL22-shRNA

Cat No
shAAV-204433

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human CCL22.

shAAV-204433

AAV-h-CCL22-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human CCL22 (C-C motif chemokine ligand 22). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

A-152E5.1; ABCD-1; DC/B-CK; MDC; SCYA22; STCP-1

Description (Vector)

CCL22 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology.

Gene ID

6367

Gene Name (Vector)

C-C motif chemokine ligand 22

Gene Symbol

CCL22

HGNC ID

HGNC:10621

ORF Size (aa)

282

RefSeq ID

NM_002990

RefSeq Synonyms

NM_002990, BC027952,

Species

human

UniGene ID

Hs.534347

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.