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human FOXP3 shRNA silencing AAV

Name 
AAV-h-FOXP3-shRNA
Cat No 
shAAV-204297
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human FOXP3.

shAAV-204297
AAV-h-FOXP3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human FOXP3 (forkhead box P3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AIID; DIETER; forkhead box protein P3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; PIDX; scurfin; XPID
Description (eCommerce)
FOXP3 is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). It plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. FOXP3 can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases.  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BZS1].
Description (Vector)
FOXP3 is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
50943
Gene Name (eCommerce)
forkhead box P3
Gene Name (Vector)
forkhead box P3
Gene Symbol
FOXP3
HGNC ID
HGNC:6106
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1296
ORF Size (bp)
1296 bp
Protein Name (eCommerce)
Forkhead box protein P3
RefSeq ID
NM_014009
RefSeq Synonyms
NM_014009, NM_001114377, BC143786, BC143785, BC113403, BC113401, BC111853,
Research Areas
Cancer,Chromatin Remodeling,Histone Modification,Host-Virus Interactions,Immunology,Interleukin Signaling,Neurobiology,Neurodevelopment,Response to Virus,Signal Transduction,T-cell Receptor Signaling,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,transcription_translation,genetics,infectious_disease,immunology,signal_transduction,neurobiology,developmental_biology,infectious_disease,signal_transduction,immunology,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
FOXP3 is a transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). It plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. FOXP3 can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases.  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BZS1].
UniGene ID
Hs.247700
UniProt ID (eCommerce)
Q9BZS1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.